Catalytic Enantioselective Allylic C–F Bond Functionalization

Catalytic enantioselective defluorinative functionalization of easily accessible allylic fluorines is well recognized as one the most attractive strategies for creating stereogenic centers with high enantioselectivity. This highlight review precisely aims to summarize recent developments this area mainly from following six aspects: defluoroarylation, defluoroalkylation, defluoroborylation, defluorosilylation, defluorohydrolation, and desymmetrization difluoromethylene groups. Primarily, these reactions occur through two pathways, including ?-fluorine elimination C–F oxidative addition. Despite this, mechanisms limitations have been a focus, it hoped that will provide comprehensive overview evaluate prospects rapidly emerging field. asymmetric has centers. area. We hope can